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Effect of aspirin on the disposition of tetracycline in sheep

Effect of aspirin on the disposition of tetracycline in sheep

Iranian Journal of Veterinary Research 5(2): 86-90

Aspirin has been shown to increase the rate of urinary excretion of tetracycline in humans. To understand the mechanisms involved in this drug interaction, the effect of aspirin on the kinetics of tetracycline was investigated in sheep. Tetracycline was administered intravenously in 6 mixed-breed sheep at various stages: tetracycline alone, immediately after intravenous injection of salicylic acid and at 3 h following oral administration of tetracycline.

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Accession: 004118519

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