+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Effect of time of initiation and dose of prenatal iron and folic acid supplementation on iron and folate nutriture of Korean women during pregnancy



Effect of time of initiation and dose of prenatal iron and folic acid supplementation on iron and folate nutriture of Korean women during pregnancy



American Journal of Clinical Nutrition 82(4): 843-849



BACKGROUND: In Korea, it is customary to prescribe iron and folic acid supplements to pregnant women after the 20th wk of gestation; however, little evidence exists to support this practice. OBJECTIVE: The objective was to determine the effects of time of initiation and dose of prenatal iron and folic acid supplementation on the iron and folate nutriture of Korean women during pregnancy. DESIGN: A total of 131 pregnant women were placed into 1 of 5 experimental groups, either the control group or 1 of 4 supplemented groups. The supplemented groups varied by time of initiation, which was either during the first trimester or at week 20 of gestation, and by dose of iron and folic acid supplements provided, which consisted of either 30 mg Fe plus 175 [micro]g folic acid or 60 mg Fe plus 350 [micro]g folic acid. All supplemented groups continued supplementation until delivery. RESULTS: Improvements in iron and folate nutriture were highly dependent on when the supplement program was initiated, but both supplement doses were equally effective. In contrast, the influence of folic acid supplementation on maternal folate status was not as pronounced as was the influence of iron supplementation on iron status. CONCLUSION: In pregnant Korean women, initiating iron and folic acid supplementation earlier during pregnancy may prevent the deterioration of iron and folate nutriture more than does increasing supplement doses in later stages of pregnancy.

(PDF emailed within 0-6 h: $19.90)

Accession: 004128831

Download citation: RISBibTeXText

PMID: 16210715

DOI: 10.1093/ajcn/82.4.843


Related references

Folate and iron status of non-anemic women during pregnancy: Effect of routine folate and iron supplementation and relation of erythrocyte folate with iron stores. Nutrition Research 16(8): 1267-1276, 1996

Effects and safety of preventive oral iron or iron+folic acid supplementation for women during pregnancy. Cochrane Database of Systematic Reviews 2010(4): Cd004736, 2010

Changes in iron status during pregnancy in peruvian women receiving prenatal iron and folic acid supplements with or without zinc. American Journal of Clinical Nutrition 71(4): 956-961, 2000

Changes in iron status during pregnancy in Peruvian women receiving prenatal iron and folic acid supplements with or without zinc. The American Journal of Clinical Nutrition 71(4): 956-961, 2000

Daily Maternal Lipid-Based Nutrient Supplementation with 20 mg Iron, Compared with Iron and Folic Acid with 60 mg Iron, Resulted in Lower Iron Status in Late Pregnancy but Not at 6 Months Postpartum in Either the Mothers or Their Infants in Bangladesh. Journal of Nutrition 148(10): 1615-1624, 2018

Weekly iron-folic acid supplementation to improve iron status and prevent pregnancy anemia in Filipino women of reproductive age: the Philippine experience through government and private partnership. Nutrition Reviews 63(12 Pt 2): S109-S115, 2006

Weekly iron-folic acid supplementation to improve iron status and prevent pregnancy anemia in Filipino women of reproductive age: the Philippine experience through government and private partnership. Nutrition Reviews 63(12(II)): S109-S115, 2005

Iron Supplementation in Twin Pregnancy - The Benefit of Doubling the Iron Dose in Iron Deficient Pregnant Women: A Randomized Controlled Trial. Twin Research and Human Genetics 20(5): 419-424, 2017

Effects of routine oral iron supplementation with or without folic acid for women during pregnancy. Cochrane Database of Systematic Reviews 2006(3): Cd004736, 2006

Kinetics of folate turnover in pregnant women (second trimester) and nonpregnant controls during folic acid supplementation: stable-isotopic labeling of plasma folate, urinary folate and folate catabolites shows subtle effects of pregnancy on turnover of folate pools. Journal of Nutrition 131(7): 1928-1937, 2001

Maternal zinc, iron, folic acid, and protein nutriture and outcome of human pregnancy. American Journal of Clinical Nutrition 40(3): 496-507, 1984

Factors associated with prenatal folic acid and iron supplementation among 21,889 pregnant women in Northern Tanzania: a cross-sectional hospital-based study. Bmc Public Health 12: 481-481, 2012

Effect of routine iron supplementation with or without folic acid on anemia during pregnancy. Bmc Public Health 11 Suppl 3: S21, 2011

Government-industry partnership in weekly iron-folic acid supplementation for women of reproductive age in the Philippines: impact on iron status. Nutrition Reviews 63(12(II)): S116-S125, 2005

Government-industry partnership in weekly iron-folic acid supplementation for women of reproductive age in the Philippines: impact on iron status. Nutrition Reviews 63(12 Pt 2): S116-S125, 2006