Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis

Gavaldà, J.; Martín, M.ía.-T.; López, P.; Gomis, X.; Ramírez, J.é-L.ís.; Rodríguez, D.; Len, O.; Puigfel, Y.; Ruíz, I.; Pahissa, A.

Antimicrobial Agents and ChemoTherapy 49(7): 3028-3030


ISSN/ISBN: 0066-4804
PMID: 15980392
DOI: 10.1128/aac.49.7.3028-3030.2005
Accession: 004140226

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The efficacy of therapeutic aerosolized amphotericin B (AMB) was studied in a steroid-immunosuppressed murine model of invasive pulmonary aspergillosis. Nebulized liposomal AMB can be a valid approach to the treatment of this infection, with subjects showing significantly improved survival relative to that of subjects given intravenous deoxycholate AMB, as well as lower lung weights and pulmonary glucosamine levels.