Efficacy of voriconazole plus amphotericin B or micafungin in a guinea-pig model of invasive pulmonary aspergillosis

Chandrasekar, P.H.; Cutright, J.L.; Manavathu, E.K.

Clinical Microbiology and Infection the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 10(10): 925-928

2004


ISSN/ISBN: 1198-743X
PMID: 15373889
DOI: 10.1111/j.1469-0691.2004.00958.x
Accession: 004140508

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Abstract
The efficacy of voriconazole in combination with amphotericin B or micafungin was studied in a transiently neutropenic guinea-pig model of invasive pulmonary aspergillosis. Guinea-pigs treated with the antifungal drugs, alone or in two-drug combinations, had an improved survival rate and reduced fungal burden in the lungs compared to untreated control animals. The efficacy of monotherapy and combination therapy was similar; activity was neither enhanced nor reduced with the two-drug combinations. Further studies of efficacy, dosing and optimal regimens for antifungal combinations are warranted.

Efficacy of voriconazole plus amphotericin B or micafungin in a guinea-pig model of invasive pulmonary aspergillosis