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Efficiency of mammalian selenocysteine incorporation



Efficiency of mammalian selenocysteine incorporation



Journal of Biological Chemistry 279(36): 37852-9



Five components have thus far been identified that are necessary for the incorporation of selenocysteine (Sec) into ~25 mammalian proteins. Two of these are cis sequences, a SECIS element in the 3'-untranslated region and a Sec codon (UGA) in the coding region. The three known trans-acting factors are a Sec-specific translation elongation factor (eEFSec), the Sec-tRNASec, and a SECIS-binding protein, SBP2.

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Accession: 004140675

Download citation: RISBibTeXText

PMID: 15229221

DOI: 10.1074/jbc.M404639200


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