+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar: G6PD Mahidol (487G>A) is the most common variant in the Myanmar population

Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar: G6PD Mahidol (487G>A) is the most common variant in the Myanmar population

Journal of Human Genetics 49(10): 544-547

We conducted a survey of malaria diagnoses and treatments in remote areas of Myanmar. Blood specimens from more than 1,000 people were collected by the finger-prick method, and 121 (11%) of these people were found to be glucose-6-phosphate dehydrogenase (G6PD) deficient. Of these 121, 50 consented to analysis of the G6PD genome. We read the G6PD sequences of these subjects and found 45 cases of G6PD Mahidol (487G>A), two of G6PD Coimbra (592C>T), two of G6PD Union (1360C>T), and one of G6PD Canton (1376G>T). Taken together with data from our previous report, 91.3% (73/80) of G6PD variants were G6PD Mahidol. This finding suggests that the Myanmar population is derived from homogeneous ancestries and are different from Thai, Malaysian, and Indonesian populations.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 004178098

Download citation: RISBibTeXText

PMID: 15349799

DOI: 10.1007/s10038-004-0187-7

Related references

Glucose-6-phosphate dehydrogenase (G6PD) mutations in Cambodia: G6PD Viangchan (871G>A) is the most common variant in the Cambodian population. Journal of Human Genetics 50(9): 468-472, 2005

Glucose-6-phosphate dehydrogenase (G6PD) mutations in Thailand: G6PD Viangchan (871G>A) is the most common deficiency variant in the Thai population. Human Mutation 19(2): 185, 2002

Hemolytic Potential of Tafenoquine in Female Volunteers Heterozygous for Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency ( G6PD Mahidol Variant) versus G6PD-Normal Volunteers. American Journal of Tropical Medicine and Hygiene 97(3): 702-711, 2017

Glucose 6-phosphate dehydrogenase variants: a unique variant (G6PD Kobe) showed an extremely increased affinity for galactose 6-phosphate and a new variant (G6PD Sapporo) resembling G6PD Pea Ridge. Human Genetics 58(4): 405-407, 1981

Molecular genetics of the glucose-6-phosphate dehydrogenase (G6PD) Mediterranean variant and description of a new G6PD mutant, G6PD Andalus1361A. American Journal of Human Genetics 47(3): 575-579, 1990

Purification and detailed study of two clinically different human glucose 6-phosphate dehydrogenase variants, G6PD(Plymouth) and G6PD(Mahidol): Evidence for defective protein folding as the basis of disease. Molecular Genetics and Metabolism 93(1): 44-53, 2007

Glucose-6-phosphate dehydrogenase variants: reexamination of G6PD Chicago and Cornell and a new variant (G6PD Pea Ridge) resembling G6PD Chicago. Blood 55(2): 216-220, 1980

Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among malaria patients in Upper Myanmar. Bmc Infectious Diseases 18(1): 131, 2018

The use of primaquine in malaria infected patients with red cell glucose-6-phosphate dehydrogenase (G6PD) deficiency in Myanmar. Southeast Asian Journal of Tropical Medicine and Public Health 25(4): 710-713, 1994

Characterization of glucose-6-phosphate dehydrogenase variants. I. Occurrence of a G6PD Seattle-like variant in Sardinia and its interaction with the G6PD Mediterranean variant. American Journal of Human Genetics 21(2): 142-153, 1969

Frequency of glucose 6-phosphate dehydrogenase (G6PD) deficiency in Tokyo and a new variant: G6PD Musashino. Nihon Ketsueki Gakkai Zasshi 50(1): 25-28, 1987

Frequency of glucose 6 phosphate dehydrogenase g6pd deficiency in tokyo japan and a new variant g6pd musashino. Acta Haematologica Japonica 50(1): 25-28, 1987

A new glucose 6-phosphate dehydrogenase(G6PD) variant(G6PD Niigata) with chronic hemolysis and liver hemochromatosis. Nihon Naika Gakkai Zasshi 78(1): 41-47, 1989

A new glucose 6-phosphate dehydrogenase (G6PD) variant (G6PD Niigata) with chronic hemolysis and liver hemochromatosis. Nihon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine 78(1): 41-47, 1989

Glucose-6-phosphate dehydrogenase (G6PD) mutations associated with F8C/G6PD haplotypes in Chinese. Blood 85(12): 3767-3768, 1995