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Novel inhalational murine model of invasive pulmonary aspergillosis



Novel inhalational murine model of invasive pulmonary aspergillosis



Antimicrobial Agents and ChemoTherapy 48(5): 1908-1911



We developed a novel model of invasive aspergillosis (IA) that recapitulates human disease. Mice were immunosuppressed with cyclophosphamide and cortisone acetate and then infected in an aerosol chamber. This procedure reproducibly delivered 1x103 to 3x103 conidia to the lungs. Lethal pulmonary IA developed over 2 weeks and was prevented by amphotericin B.

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Accession: 004251182

Download citation: RISBibTeXText

PMID: 15105158

DOI: 10.1128/aac.48.5.1908-1911.2004


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