Section 5
Chapter 4,266

Peroxisome proliferator-activated receptor alpha: transcription factor determining the fate of fatty acids

Cabrero, A.; Jove, M.; Planavila, A.; Vazquez Carrera, M.

Recent Research Developments in Biophysics and Biochemistry, Vol 3, Part I: 65-74


Accession: 004265711

Download citation:  

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors, which form a subfamily of the nuclear receptor gene family. This subfamily consists of three isotypes, alpha (NR1C1), gamma (NR1C3), and delta / beta (NRC1C2) with a differential tissue distribution. PPAR alpha is expressed primarily in tissues with a high level of fatty acid catabolism such as liver, brown fat, kidney, heart and skeletal muscle. PPAR delta / beta is ubiquitously expressed, and PPAR gamma has a restricted pattern of expression, mainly in white and brown adipose tissues, whereas other tissues such as skeletal muscle and heart contain limited amounts.

Full Text Article emailed within 1 workday: $29.90