Section 5
Chapter 4,280

Preliminary experience with low concentration of granulocyte-macrophage colony-stimulating factor: a potential regulator in preimplantation mouse embryo development and apoptosis

Behr, B.; Mooney, S.; Wen, Y.; Polan, M.Lake.; Wang, H.

Journal of Assisted Reproduction and Genetics 22(1): 25-32


ISSN/ISBN: 1058-0468
PMID: 15807219
DOI: 10.1007/s10815-005-0817-9
Accession: 004279178

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Purpose: To investigate the effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on the development of preimplantation mouse embryos. Methods: Mouse 2-cell embryos were collected and cultured in P-1 medium supplemented with GM-CSF at different concentrations. Using reverse transcription-polymerase chain reaction, expression Bcl-2 and Bax mRNA in blastocyst were evaluated in the GM-CSF group and control group.

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