+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscular problems



Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscular problems



British Journal of Clinical Pharmacology 57(4): 525-528



Muscular problems are the major group of side-effects during statin treatment. They are known to occur much more frequently during and after exercise. For the last 8 years we have monitored 22 professional athletes in whom, because of familial hypercholesterolaemia, treatment with different statins was attempted. Only six out of the 22 finally tolerated at least one member of this family of drugs. In three of these six the first statin prescribed allowed training performance without any limitation. Changing the drug demonstrated that only two tolerated all the four or five statins examined (atorvastatin, fluvastatin, lovastatin, pravastatin, simvastatin). Cerivastatin was not among the statins prescribed. These findings indicate that in top sports performers only about 20% tolerate statin treatment without side-effects. Clinical decision making as to lipid lowering therapy thus becomes a critical issue in this small subgroup of patients.

(PDF emailed within 0-6 h: $19.90)

Accession: 004284709

Download citation: RISBibTeXText

PMID: 15025753

DOI: 10.1111/j.1365-2125.2003.02044.x


Related references

Early initiation of statin treatment in children with familial hypercholesterolaemia. Current Opinion in Lipidology 26(3): 236-239, 2016

Long term statin treatment reduces lipoprotein(a) concentrations in heterozygous familial hypercholesterolaemia. Heart 89(8): 893-896, 2003

Statin treatment for children and adolescents with heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis. Atherosclerosis 195(2): 339-347, 2006

Effect of statin treatment for familial hypercholesterolaemia on life assurance: results of consecutive surveys in 1990 and 2002. Bmj 328(7438): 500-501, 2004

Evolution of thoracic aortic atherosclerosis over intermediate-term follow-up in patients with heterozygous familial hypercholesterolaemia receiving statin treatment. European Heart Journal 22(Abstract Supplement): 269, September, 2001

Cost-effectiveness analysis of the use of a high-intensity statin compared to a low-intensity statin in the management of patients with familial hypercholesterolaemia. Current Medical Research and Opinion 26(3): 529-536, 2010

Problems of long-term treatment in children with familial hypercholesterolaemia. Progress in Clinical and Biological Research 188: 209-211, 1985

Inflammatory markers in patients with familial hypercholesterolaemia and the effect of statin therapy. Clinical Chemistry & Laboratory Medicine 39(Special Supplement): S303, 2001

Homozygous familial hypercholesterolaemia: Spanish adaptation of the position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society. Consensus document of the Spanish Society of Arteriosclerosis (SEA) and Familial Hypercholesterolaemia Foundation (FHF). Clinica E Investigacion en Arteriosclerosis 27(2): 80-96, 2016

Quality of life, anxiety and concerns among statin-treated children with familial hypercholesterolaemia and their parents. Acta Paediatrica 92(9): 1096-1101, September, 2003

Evolution of thoracic aorta atherosclerosis in patients with heterozygous familial hypercholesterolaemia after statin therapy. European Heart Journal 18(ABSTR SUPPL ): 439, 1997

Prospective randomised cross-over comparison of three different LDL-apheresis systems in statin pretreated patients with familial hypercholesterolaemia. Kidney & Blood Pressure Research 23(3-5): 304, 2000

Prospective randomised cross-over comparison of three LDL-apheresis systems in statin pretreated patients with familial hypercholesterolaemia. Atherosclerosis 151(2): 493-499, August, 2000

Effect of omega-3 fatty acid supplementation on arterial elasticity in patients with familial hypercholesterolaemia on statin therapy. Nutrition, Metabolism, and Cardiovascular Diseases 26(12): 1140-1145, 2016