Regulation of branched-chain amino acid metabolism and pharmacological effects of branched-chain amino acids
Shimomura, Y.; Murakami, T.; Nagasaki, M.; Honda, T.; Goto, H.; Kotake, K.; Kurokawa, T.; Nonami, T.
Hepatology Research the Official Journal of the Japan Society of Hepatology 30s: 3-8
ISSN/ISBN: 1386-6346 PMID: 15607132 DOI: 10.1016/j.hepres.2004.09.001
Significant evidence of the pharmacological and physiological effects of branched-chain amino acids (BCAA) has accumulated, attracting the interest of not only clinicians but also basic medical researchers. We summarize here the characteristic features of BCAA catabolism, focusing on the initial two enzymes in the pathway, branched-chain aminotransferase and branched-chain alpha-keto acid dehydrogenase complex. In addition, we describe a unique characteristic of the valine catabolic pathway. Finally, we present evidence obtained in animal studies that indicates that BCAA treatment may be appropriate for liver cirrhosis, but not acute liver failure.