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Transformation of lactulose trihydrate into anhydrous lactulose by fluidized bed drying and its characterization

Transformation of lactulose trihydrate into anhydrous lactulose by fluidized bed drying and its characterization

Carbohydrate Research 339(6): 1069-1075

Stable anhydrous lactulose was produced from lactulose trihydrate by stepwise heating on a fluidized bed. The processes were performed on stable powder forms. The anhydrous lactulose was characterized by an opaque white appearance, a coarse surface structure with random cracks and indentations, a high degree of crystallization, stability under humid conditions, and by X-ray powder diffraction, differential thermal analysis, and differential thermogravimetry. Those characteristics were different from those of the original trihydrate, which was transparent, had a smooth surface and a higher degree of crystallization, was stable under humid conditions and had different X-ray powder diffraction, differential thermal analysis, and thermogravimetric characteristics. The transformation was enhanced when the inlet temperature was 45-55 degrees C or when the temperature of the fluidized bed was over 40 degrees C. At these cutoff temperatures, both crystalline forms were observed.

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Accession: 004371123

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PMID: 15063193

DOI: 10.1016/j.carres.2004.01.018

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