+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery



Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery



Journal of Clinical Investigation 113(1): 65-73



Avicins are proapoptotic and antiinflammatory triterpene electrophiles isolated from an Australian desert tree, Acacia victoriae.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 004373380

Download citation: RISBibTeXText

PMID: 14702110


Related references

Triterpenoid electrophiles (avicins) suppress heat shock protein-70 and x-linked inhibitor of apoptosis proteins in malignant cells by activation of ubiquitin machinery: implications for proapoptotic activity. Clinical Cancer Research 11(5): 1953-1962, 2005

Avicins, a proapoptotic molecule regulates cellular redox to protect cells from oxidative stress. Proceedings of the American Association for Cancer Research Annual Meeting 44: 1293-1294, 2003

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds. Carcinogenesis 30(9): 1571-1580, 2009

Proapoptotic triterpene electrophiles (avicins) form channels in membranes: cholesterol dependence. Biophysical Journal 88(4): 2577-2584, 2005

Regulation of the cellular stress response by reactive electrophiles. The role of covalent binding and cellular thiols in transcriptional activation of the 70-kilodalton heat shock protein gene by nephrotoxic cysteine conjugates. Journal of Biological Chemistry 267(34): 24322-7, 1992

Global changes in gene regulation demonstrate that unconjugated bilirubin is able to upregulate and activate select components of the endoplasmic reticulum stress response pathway. Journal of Biochemical and Molecular Toxicology 24(2): 73-88, 2010

Natural triterpenoid avicins selectively induce tumor cell death. Communicative and Integrative Biology 3(3): 205-208, 2010

Avicins Novel triterpenoid saponins from Acacia victoriae induce apoptosis by mitochondrial perturbation. Proceedings of the American Association for Cancer Research Annual Meeting (41): 600, 2000

Avicins: triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation. Proceedings of the National Academy of Sciences of the United States of America 98(10): 5821-5826, 2001

Novel insights into the regulation of antioxidant-response-element-mediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2. Biochemical Journal 440(2): 167-174, 2012

Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model. Proceedings of the National Academy of Sciences of the United States of America 98(20): 11551-6, 2001

Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles. Bioconjugate Chemistry 21(7): 1121-1129, 2010

Redox regulation of cellular stress response in multiple sclerosis. Biochemical Pharmacology 82(10): 1490-1499, 2011

Redox regulation of cellular stress response in neurodegenerative disorders. Italian Journal of Biochemistry 55(3-4): 263-282, 2007

Cellular redox regulation, signaling, and stress response in plants. Bioscience, Biotechnology, and Biochemistry 78(9): 1457-1470, 2015