Use of a synthetic peptide epitope of Asp f 1, a major allergen or antigen of Aspergillus fumigatus, for improved immunodiagnosis of allergic bronchopulmonary aspergillosis
Madan, T.; Priyadarsiny, P.; Vaid, M.; Kamal, N.; Shah, A.; Haq, W.; Katti, S.Bandacharya.; Sarma, P.Usha.
Clinical and Diagnostic Laboratory Immunology 11(3): 552-558
ISSN/ISBN: 1071-412X PMID: 15138181 DOI: 10.1128/cdli.11.3.552-558.2004
Allergic bronchopulmonary aspergillosis (ABPA) is an immunologically complex allergic disorder caused by the fungal pathogen Aspergillus fumigatus. Elevated levels of total immunoglobulin E (IgE), specific IgE, and IgG antibodies in sera are important immunodiagnostic criteria for ABPA. International reference standards or standardized immunodiagnostic assays are not available due to a lack of well-defined diagnostic antigens. The present study was carried out to identify and evaluate the immunodiagnostic relevance of synthetic epitopic peptides of Asp f 1, a major allergen, antigen, or cytotoxin of A. fumigatus.