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Virulence differences between monkeypox virus isolates from West Africa and the Congo basin

Virulence differences between monkeypox virus isolates from West Africa and the Congo basin

Virology 340(1): 46-63

ISSN/ISBN: 0042-6822

PMID: 16023693

DOI: 10.1016/j.virol.2005.05.030

Studies indicate that West African and Congo basin isolates of monkeypox virus (MPXV) are genetically distinct. Here, we show Congo basin MPXV-ZAI-V79 is more virulent for cynomolgus monkeys as compared to presumed West African MPXV-COP-58. This finding may explain the lack of case-fatalities in the U.S. 2003 monkeypox outbreak, which was caused by a West African virus.

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Accession: 004383609

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