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Vitamin intervention for stroke prevention


, : Vitamin intervention for stroke prevention. Journal of the Neurological Sciences 203/204: 121-124

Vitamin Intervention for Stroke Prevention (VISP) is designed to determine whether the utilization of folic acid, vitamins B<sub>6</sub> and B<sub>12</sub>, in addition to other risk factor reducing measures, have a demonstrable effect on prevention of recurrent stroke.

Accession: 004384327

PMID: 12417369

DOI: 10.1016/s0022-510x(02)00265-4

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Lee, M.; Markovic, D.; Ovbiagele, B., 2013: Impact and interaction of low estimated GFR and B vitamin therapy on prognosis among ischemic stroke patients: the Vitamin Intervention for Stroke Prevention (VISP) trial. Low estimated glomerular filtration rate (eGFR) has been linked to higher risk of primary stroke, but little is known about the relation of low eGFR to recurrent vascular risk after stroke. B Vitamin therapy has been used to lower homocysteine lev...

Howard, V.J.; Furie, K.L.; Wang, C-Hua.; Sides, E.G.; Toole, J.F., 2006: The changing risk factor profile of participants enrolled in a secondary stroke prevention trial: Vitamin intervention for stroke prevention. Objective: To determine if the stroke risk factor profile of participants in a large, multicenter secondary stroke prevention trial changed over the recruitment period.Methods: The 3,680 participants in the Vitamin Intervention for Stroke Prevent...

Toole, J.F.; Malinow, M.R.; Chambless, L.E.; Spence, J.D.; Pettigrew, L.C.; Howard, V.J.; Sides, E.G.; Wang, C.H.; Stampfer, M., 2004: Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the vitamin intervention for stroke prevention (VISP) randomized controlled trial. In observational studies, elevated plasma total homocysteine levels have been positively associated with ischemic stroke risk. However the utility of homocysteine-lowering therapy to reduce that risk has not been confirmed by randomized trials. To...

Toole, J.F.; Malinow, M.René.; Chambless, L.E.; Spence, J.David.; Pettigrew, L.Creed.; Howard, V.J.; Sides, E.G.; Wang, C-Hua.; Stampfer, M., 2004: Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. In observational studies, elevated plasma total homocysteine levels have been positively associated with ischemic stroke risk. However the utility of homocysteine-lowering therapy to reduce that risk has not been confirmed by randomized trials. To...

Malinow, M.R.ne; Chambless, L.E.; Howard, V.J.; Toole, J.F., 1999: Screening of plasma homocyst ine levels in stroke patients for the vitamin intervention for stroke prevention clinical trial. Stroke 30(1): 258, Jan

Keene, K.L.; Chen, W-Min.; Chen, F.; Williams, S.R.; Elkhatib, S.D.; Hsu, F-Chi.; Mychaleckyj, J.C.; Doheny, K.F.; Pugh, E.W.; Ling, H.; Laurie, C.C.; Gogarten, S.M.; Madden, E.B.; Worrall, B.B.; Sale, M.M., 2014: Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial. B vitamins play an important role in homocysteine metabolism, with vitamin deficiencies resulting in increased levels of homocysteine and increased risk for stroke. We performed a genome-wide association study (GWAS) in 2,100 stroke patients from...

Lutsep, H.L.; Campbell, S.; Chambless, L.E.; Howard, V.J.; Toole, J.F., 2005: Plasma total homocysteine levels in stroke patients screened for the vitamin intervention for stroke prevention clinical trial in the era of folate fortification. Folic acid fortification of grain products was mandated in the USA by January 1998 and in Canada by November 1998. It was hypothesized that screening total plasma homocysteine levels adjusted for age, sex, race and country that were drawn in strok...

Pettigrew, L.C.; Bang, H.; Chambless, L.E.; Howard, V.J.; Toole, J.F., 2008: Assessment of pre- and post-methionine load homocysteine for prediction of recurrent stroke and coronary artery disease in the Vitamin Intervention for Stroke Prevention Trial. Methionine (Met) loading increases total plasma homocysteine (tHcy) and assesses homocysteine metabolism. We tested the hypothesis that pre- or post-Met tHcy will predict recurrent stroke or coronary artery disease (CAD) in a subgroup analysis of...

Toole, J.F., 2002: Vitamin intervention for stroke prevention The VISP trial. Journal of the Neurological Sciences (203-204): 334-335, November 15

Spence, J.David.; Bang, H.; Chambless, L.E.; Stampfer, M.J., 2005: Vitamin Intervention For Stroke Prevention trial: an efficacy analysis. Background and Purpose - The Vitamin Intervention for Stroke Prevention trial (VISP) intention-to-treat analysis did not show efficacy of combined vitamin therapy for recurrent vascular events in patients with nondisabling stroke. Reasons for lack...