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Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity

Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity

Chemical Research in Toxicology 18(9): 1395-1404

ISSN/ISBN: 0893-228X

PMID: 16167831

DOI: 10.1021/tx050039n

In the present study, we investigated the effect of anthocyanidins on human topoisomerases I and II and its relevance for DNA integrity within human cells. Anthocyanidins bearing vicinal hydroxy groups at the B-ring (delphinidin, DEL; cyanidin, CY) were found to potently inhibit the catalytic activity of human topoisomerases I alpha and II beta , without discriminating between the II and the II isoforms.

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Accession: 004397984

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