Association of serum C-reactive protein (CRP) with some nutritional parameters of maintenance hemodialysis patients

Azar Baradaran; Hamid Nasri

Pakistan Journal of Nutrition 4(3): 175-182


Accession: 004400671

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A cross-sectional study was conducted to investigate the association between serum C-reactive protein (CRP) level and some nutritional variables in diabetic and nondiabetic end-stage renal failure patients undergoing regular haemodialysis (HD). 36 maintenance HD patients (15 women and 21 men; mean age 46.6+or-17 years), including 25 nondiabetic and 11 diabetic patients, were studied [Iran; date not given]. A near significant difference in serum CRP levels between diabetic and nondiabetic patients was observed, with higher levels in diabetics. Serum CRP levels were significantly higher in diabetic than nondiabetic female patients, and in male than female nondiabetic patients. Serum CRP level was inversely correlated with serum cholesterol and triglyceride levels, and was positively correlated with serum alkaline phosphatase and serum intact parathyrin. In addition, serum CRP was inversely correlated with dialysis efficacy. No significant association between serum CRP and serum albumin was observed. The positive correlation between high serum parathyrin level and inflammation implies the further need to control hyperphosphataemia and secondary hyperparathyroidism in HD patients. In addition, the inverse correlation of serum CRP with cholesterol and triglyceride further supports the malnutrition-inflammation complex syndrome, which is frequently seen in HD patients.