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Inhibitory effect of CDA-II, a urinary preparation, on aflatoxin B(1)-induced oxidative stress and DNA damage in primary cultured rat hepatocytes



Inhibitory effect of CDA-II, a urinary preparation, on aflatoxin B(1)-induced oxidative stress and DNA damage in primary cultured rat hepatocytes



Food and Chemical Toxicology 44(4): 546-551



The effects of CDA-II (cell differentiation agent II; a urinary preparation) on both aflatoxin B1 (AFB1)-induced cell injury and DNA damage were investigated using cultured rat hepatocytes. CDA-II was able to suppress both the lipid peroxidation and lactate dehydrogenase leakage induced by AFB1. Glutathione (GSH) depletion by AFB1 was replenished by CDA-II treatment. Under these experimental conditions, CDA-II enhanced the activity of GSH peroxidase, but not GSH S-transferase.

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Accession: 004443470

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PMID: 16229933

DOI: 10.1016/j.fct.2005.08.029


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