Role of glutamate and dopamine receptors in the psychopharmacological profile of the indole alkaloid psychollatine

Both, F.L.; Meneghini, L.; Kerber, V.A.; Henriques, Aélia.T.; Elisabetsky, E.

Journal of Natural Products 69(3): 342-345


ISSN/ISBN: 0163-3864
PMID: 16562831
DOI: 10.1021/np050291v
Accession: 004470230

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Psychollatine (1), a new glycoside indole monoterpene alkaloid isolated from Psychotria umbellata, has shown an interesting psychopharmacological profile. This study aimed to investigate the role of NMDA glutamate and dopamine receptors in mediating the properties of 1. Psychollatine (1) was assessed for NMDA-induced seizures, MK-801-induced hyperlocomotion, amphetamine-induced lethality, and apomorphine-induced climbing behaviour in mice. Psychollatine (1) (100 mg/kg) and MK-801 (0.3 mg/kg) prevented NMDA-induced seizures (P<0.01), while 1 (100 mg/kg) attenuated the MK-801-induced hyperlocomotion (P<0.05). Compound 1 (3 and 10 mg/kg), as well as chlorpromazine (4 mg/kg), prevented amphetamine-induced lethality (P<0.05). Finally, 1 (10 mg/kg) (P<0.05), MK-801 (0.2 mg/kg) (P<0.01), and chlorpromazine (4 mg/kg) (P<0.01) attenuated apomorphine-induced climbing behaviour. The present results strongly support the involvement of NMDA glutamate receptors in the mode of action of psychollatine (1).