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Neuroprotective effects of N-acetylcysteine on experimental closed head trauma in rats

Neuroprotective effects of N-acetylcysteine on experimental closed head trauma in rats

Neurochemical Research 31(4): 473-481

N-acetylcysteine (NAC) is a precursor of glutathione, a potent antioxidant, and a free radical scavenger. The beneficial effect of NAC on nervous system ischemia and ischemia/reperfusion models has been well documented. However, the effect of NAC on nervous system trauma remains less understood. Therefore, we aimed to investigate the therapeutic efficacy of NAC with an experimental closed head trauma model in rats.

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Accession: 004521020

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PMID: 16758355

DOI: 10.1007/s11064-006-9040-z

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