+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

The variant surface glycoprotein as a tool for adaptation in African trypanosomes

The variant surface glycoprotein as a tool for adaptation in African trypanosomes

Microbes and Infection 8(3): 930-937

African trypanosomes (prototype: Trypanosoma brucei) are flagellated protozoan parasites that infect a wide variety of mammals, causing nagana in cattle and sleeping sickness in humans. These organisms can cause prolonged chronic infections due to their ability to successively expose different antigenic variants of the variant surface glycoprotein (VSG). The genomic loci where the VSG genes are expressed are telomeric and contain polycistronic transcription units with several genes that are involved in adaptation of the parasite to the host. At least three of these genes, which respectively encode the two subunits of the heterodimeric receptor for transferrin and a protein conferring resistance to the human trypanolytic factor apolipoprotein L-I, share the same origin as the VSG. The high recombination potential of the telomeric VSG expression sites, coupled to their dynamic mono-allelic expression control, provides trypanosomes with a powerful capacity for adaptation to their hosts.

(PDF emailed within 0-6 h: $19.90)

Accession: 004528757

Download citation: RISBibTeXText

PMID: 16480910

DOI: 10.1016/j.micinf.2005.10.002

Related references

Biological variation among african trypanosomes: I. Clonal expression of virulence is not linked to the variant surface glycoprotein or the variant surface glycoprotein gene telomeric expression site. Dna and Cell Biology 29(5): 215-227, 2010

Microbial surface elements: the case of variant surface glycoprotein (VSG) genes of African trypanosomes. Genetic engineering principles and methods(3): 129-155, 1981

Targeting the variable surface of African trypanosomes with variant surface glycoprotein-specific, serum-stable RNA aptamers. Eukaryotic Cell 2(1): 84-94, 2003

Maintaining the protective variant surface glycoprotein coat of African trypanosomes. Biochemical Society Transactions 33(Pt 5): 981-982, 2005

Control of variant surface glycoprotein messenger rna synthesis in african trypanosomes. Journal of Cellular Biochemistry Supplement (13 PART E): 65, 1989

Characterization of t helper cell responses to the variant surface glycoprotein vsg of african trypanosomes. FASEB Journal 6(4): A1220, 1992

On the role of repeated sequences 5' to variant surface glycoprotein genes in African trypanosomes. Gene 53(1): 55-62, 1987

Co-duplication of a variant surface glycoprotein gene and its promoter to an expression site in African trypanosomes. Journal of Biological Chemistry 272(39): 24637-24645, 1997

Biochemical and immunological characterization of the variant surface coat glycoprotein shed by African trypanosomes. Infection and Immunity 53(1): 166-172, 1986

Evolution of Antigenic Variation in African Trypanosomes: Variant Surface Glycoprotein Expression, Structure, and Function. Bioessays 1800181-E1800181, 2018

Leaky transcription of variant surface glycoprotein gene expression sites in bloodstream african trypanosomes. Journal of Biological Chemistry 274(24): 16884-16893, 1999

Analysis of a donor gene region for a variant surface glycoprotein and its expression site in African trypanosomes. Nucleic Acids Research 29(10): 2012-2019, 2001

Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America 102(24): 8716-8721, 2005

The soluble variant surface glycoprotein released by African trypanosomes fails to alarm the innate immune system. FASEB Journal 17(7): C55, April 14, 2003

Differences in resistance to African trypanosomes are not directly linked to variant surface glycoprotein specific TH cell responses. FASEB Journal 10(6): A1183, 1996