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1 2 di methyl hydrazine induced tumors in cba mice



1 2 di methyl hydrazine induced tumors in cba mice



Voprosy Onkologii (Stsburg). 1977; 23(7): 39-43



Female CBA mice were treated weekly with s.c. injections of 1,2-dimethylhydrazine (8 mg/kg body wt) for 38-40 wk. All animals but 1 developed tumors, mainly of the uterus, anal region and intestine. Uterine tumors were endometrial sarcomas, although myometrial and vascular components were also present. Large tumors of the anal region were squamous cell or basosquamous carcinomas, while small growths were sebaceous adenomas or basal cell tumors. 1,2-dimethylhydrazine appears to be a more multipotent carcinogen for mice than rats. Uterine sarcomas are of special interest in view of their rarity in mice.

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