+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

2 amino 6 trifluoromethoxybenzothiazole pk 26124 a proposed antagonist of excitatory amino acid neurotransmission does not produce phencyclidine like behavioral effects in pigeons rats and rhesus monkeys



2 amino 6 trifluoromethoxybenzothiazole pk 26124 a proposed antagonist of excitatory amino acid neurotransmission does not produce phencyclidine like behavioral effects in pigeons rats and rhesus monkeys



Neuropharmacology 27(7): 771-775



PK 26124, a proposed excitatory amino acid antagonist, was compared to mephensin and phencyclidine (PCP). In pigeons, PK 26124 and mephenesin produced loss of righting that was to some extent associated with eye closure and muscle relaxation, whereas PCP produced catalepsy, i.e., loss of righting without eye closure and without muscle relaxation. PK 26124, but not mephenesin, produced PCP-like discriminative stimulus effects in some but not all pigeons. In rats, PK 26124 and mephenesin produced loss of righting but did not induce locomotion, sniffing, swaying and falling, unlike PCP. In rhesus monkeys, PK 26124 did not induce ketamine-like discriminative stimulus effects. While PK 26124 may share some biochemical properties with excitatory amino acid antagonists these do not lead to behavioral effects similar to PCP.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 004534022

Download citation: RISBibTeXText

PMID: 2843787


Related references

MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys. Journal of Pharmacology and Experimental Therapeutics 245(3): 969-974, 1988

Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate. Life Sciences 39(11): 973-978, 1986

2 amino 6 trifluoromethoxybenzothiazole a possible antagonist of excitatory amino acid neurotransmission 1. anticonvulsant properties. Neuropharmacology 24(8): 767-774, 1985

Metaphit, a proposed phencyclidine receptor acylator: phencyclidine-like behavioral effects and evidence of absence of antagonist activity in pigeons and in rhesus monkeys. Journal of Pharmacology and Experimental Therapeutics 237(2): 386-392, 1986

Pk 26124 2 amino 6 trifluoromethoxybenzothiazole a possible glutamate antagonist. Society for Neuroscience Abstracts 10(1): 230, 1984

Behavioral and electroencephalographic effects of excitatory amino acid antagonists and sigma opiate phencyclidine like compounds in rats. Neuropharmacology 28(1): 57-62, 1989

Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate. Behavioural Brain Research 19(3): 257-259, 1986

2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--II. Biochemical properties. Neuropharmacology 24(11): 1085-1092, 1985

Effects of a series of 4 phosphonoalkylpiperidine 2 carboxylic acids in pigeons and mice selective antagonists of neurotransmission at nmda preferring excitatory amino acid receptors. Society for Neuroscience Abstracts 14(2): 942, 1988

The N-methyl-D-aspartate antagonist, 2-amino-7-phosphonoheptanoate, produces phencyclidine-like behavioral effects in rats. European Journal of Pharmacology 136(1): 133-134, 1987

Excitatory amino acid antagonists induce a phencyclidine-like catalepsy in pigeons: structure-activity studies. Neuropharmacology 26(9): 1261-1265, 1987

Electrophysiological studies of the interaction between phencyclidine sigma receptor agonists and excitatory amino acid neurotransmission on central mammalian neurons. Pharmacology Biochemistry & Behavior 28(1): 132, 1987

Schedule-controlled behavioral effects of the selective 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic acid antagonist LY293558 in pigeons. Journal of Pharmacology and Experimental Therapeutics 275(1): 164-170, 1995

Retardation of amygdaloid kindling by and the behavioral effects of kynurenic acid an antagonist of excitatory amino acids a preliminary report. Society for Neuroscience Abstracts 13(2): 761, 1987

Excitatory amino acid mediated neurotransmission functional studies in nerve cell cultures using a new quinoxalinedione antagonist fg 9041. Acta Neurologica Scandinavica 80(4): 360, 1989