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3 red cell sodium transport systems in hypertensive and normotensive utah usa adults



3 red cell sodium transport systems in hypertensive and normotensive utah usa adults



Hypertension 6(2 Part 1): 159-166



Na-Li countertransport (SLC), Na-K cotransport (CoT) and ouabain binding to Na, K-ATPase sites were measured on fresh erythrocytes from hypertensive and normotensive Utah subjects with and without a 1st-degree relative with hypertension. SLC was measured as Li+ efflux into NaCl and MgCl2 media from Li+-loaded cells (5-7 mM). CoT was measured by monitoring Na+ and K+ efflux from cells loaded to 20-30 mM Na+ and 20-30 mM K+. Ouabain binding was determined for fresh cells using 3H-ouabain. Subjects were selected from pedigrees that showed a prevalence of hypertension. SLC was significantly elevated in 26.5% of the hypertensive subjects (P < 0.001) as well as in 12.8% of the normotensives with a hypertensive 1st-degree relative (P < 0.05). Although elevated SLC and decreased CoT have previously been associated with hypertension, no hypertensive subject in this study exhibited both abnormalities. All subjects with elevated SLC had normal CoT. A positive correlation between SLC and CoT was observed. Few hypertensive subjects (11.8%) had decreased CoT. In the majority of subjects studied, both SLC and CoT were normal: hypertensives 61.8%, normotensives with a hypertensive 1st-degree relative 61.7%, and other normotensives 58.7%. The number of ouabain-binding sites was not significantly altered among hypertensives, or their relatives, even though there was a positive correlation between SLC and the number of ouabain-binding sites.

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