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5 6 epoxyeicosatrienoic acid mobilizes calcium in anterior pituitary cells

5 6 epoxyeicosatrienoic acid mobilizes calcium in anterior pituitary cells

Biochemical & Biophysical Research Communications 139(3): 1188-1194

Luteinizing hormone releasing hormone stimulates the concomitant release of luteinizing hormone and 45Ca2+ from prelabeled anterior pituitary cells. Indomethacin (10 .mu.M) and nordihydroguaiaretic acid (10 .mu.M) had no effect on luteinizing hormone releasing hormone-stimulated release of either luteinizing hormone or 45Ca2+. Eicosatetraynoic acid (10 .mu.M) blocked both luteinizing hormone releasing hormone-stmulated luteinizing hormone secretion and luteinizing hormone releasing hormone-stimulated 45Ca2+ efflux. 5,6-Epoxyeicosatrienoic acid stimulated both luteinizing hormone secretion and 45Ca2+ efflux from anterior pituitary cells. Additionally, 5,6-epoxy-eicosatrienoic acid closely mimics the ability of luteinizing hormone releasing hormone to increase intracellular free calcium. These results are consistent with the hypothesis that 5,6-EET alters calcium homeostasis in a manner similar to that observed during luteinizing hormone releasing hormone stimulation of luteinizing hormone release.

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Accession: 004543535

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