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A chondroitin sulfate proteo glycan from human cultured glial cells aggregates with hyaluronic acid

A chondroitin sulfate proteo glycan from human cultured glial cells aggregates with hyaluronic acid

Biochemical and Biophysical Research Communications 84(4): 914-921

Media harvested from cultures of glial cells grown in the presence of 35S-sulfate contain 35S-labeled proteoglycans. One of the components was a chondroitin sulfate proteoglycan that had an apparent monomer size similar to that of cartilage-derived chondroitin sulfate proteoglycan. The glial proteoglycan-formed aggregates in the presence of hyaluronic acid; aggregation was abolished in the presence of deca- to tetradecasaccharides derived from hyaluronic acid or by previous reduction and alkylation of the proteoglycan. The ability to produce large chondroitin sulfate proteoglycan molecules capable of binding to hyaluronic acid is not confined to cartilage cells.

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Accession: 004554812

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PMID: 728159

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