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A comparative study on phosphate protecting groups in oligo nucleotide synthesis by the phospho tri ester approach



A comparative study on phosphate protecting groups in oligo nucleotide synthesis by the phospho tri ester approach



Chemical and Pharmaceutical Bulletin (Tokyo) 30(8): 2991-2995



The efficiencies of various phosphate protecting groups in the synthesis of internucleotidic bonds by the phosphotriester approach were studied. In the coupling reaction using alkyl groups as phosphate protecting groups of internucleotidic bonds, extensive sulfonation of the 5'-hydroxyl group of nucleoside occurred, whereas when aryl groups were used in place of alkyl groups, the sulfonation did not occur.

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Accession: 004559872

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