A comparison between propranolol, practolol and betaxolol (SL75212) on the circulatory and metabolic responses to insulin-induced hypoglycaemia

Saunders, J.; Gomeni, R.; Kilborn, J.R.; Morselli, P.L.; Sönksen, P.H.

European Journal of Clinical Pharmacology 21(3): 177-184

1981


ISSN/ISBN: 0031-6970
PMID: 6119203
DOI: 10.1007/bf00627917
Accession: 004560380

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Abstract
Six healthy male volunteers received equivalent i.v. .beta.-blocking doses of propranolol, practolol and betaxolol (SL75212) or saline at weekly intervals. At 60 min later 0.1 U/kg insulin was given i.v. In all studies, maximum hypoglycemia (mean 1.2 mmol/l) was reached 30 min after insulin. Recovery from hypoglycemia was delayed with propranolol but practolol and betaxolol had no effect. Propranolol blocked the tachycardia and widening of pulse pressure seen in saline treated subjects. It also blocked the rebound rise in free fatty acids (FFA) and glycerol concentrations that followed the nadir of hypoglycemia. Neither practolol nor betaxolol had significant effects on pulse rate or blood pressure but betaxolol resembled propranolol in blocking the rebound rise in FFA and glycerol, while practolol blocked the rise in glycerol alone. The magnitude of the rise in growth hormone following hypoglycemia was similar in all groups, but the peak was earlier after practolol and betaxolol.

A comparison between propranolol, practolol and betaxolol (SL75212) on the circulatory and metabolic responses to insulin-induced hypoglycaemia