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A comparison of the effects of vasopressin and oxytocin with amphetamine and chlordiazepoxide on passive avoidance behavior in rats



A comparison of the effects of vasopressin and oxytocin with amphetamine and chlordiazepoxide on passive avoidance behavior in rats



Psychopharmacology 80(1): 88-92



On the basis of results obtained from passive avoidance studies, the neuropeptide vasopressin could apparently act on arousal, rather than memory processes in rats. The effects of substances that are known to increase (d-amphetamine) or decrease (chlordiazepoxide) behavioral arousal were examined, and the data with those obtained after vasopressin or oxytocin treatment were compared. All 4 substances yielded broadly similar bimodal results (although the oxytocin data failed to reach significance). An arousal interpretation is indicated, which suggests that performance and arousal are related in an inverted-U manner. Care must be taken in selecting appropriate statistical tests.

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Accession: 004564279

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PMID: 6408678



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