A comparison of the pharmacokinetics of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young healthy subjects
Rigby, J.W.; Scott, A.K.; Hawksworth, G.M.; Petrie, J.C.
British Journal of Clinical Pharmacology 20(4): 327-331
ISSN/ISBN: 0306-5251 PMID: 2866783 DOI: 10.1111/j.1365-2125.1985.tb05072.x
1 Six elderly patients with established hypertension and six young healthy subjects were studied after 8 days of treatment with atenolol 50 mg day-1, metoprolol 50 mg day-1, oxprenolol 80 mg day-1 and propranolol 80 mg day-1. 2 The area under the blood concentration-time curve was increased in the elderly group for each drug, but the difference was statistically significant only for atenolol. 3 The lower serum albumin concentrations in the elderly group did not result in a decrease in the percentage of propranolol or oxprenolol bound to serum proteins.