+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A cost comparison of clindamycin and aztreonam versus clindamycin and gentamicin in perforated or gangrenous appendicitis

A cost comparison of clindamycin and aztreonam versus clindamycin and gentamicin in perforated or gangrenous appendicitis

Current Therapeutic Research 42(4): 680-689

A previously reported clinical trial of clindamycin/aztreonam versus clindamycin/gentamicin as adjuvant therapy for surgically treated grangrenous or perforated appendicitis was analyzed for relative costs associated with the antibiotics. Total therapy costs were compared for the clindamycin/gentamicin patients, mean of $532.69 .+-. 130.00, and clindamycin/aztreonam patients, mean of $578.82 .+-. 96.99 and were found to be significantly different (P < 0.05). Acquisition costs were considerably greater for the combination of clindamycin/aztreonam, means of $417.44 .+-. 69.95, than for clindamycin/gentamicin, mean of $251.75 .+-. 67.22. Manufacturing costs for intravenous intermittent infusions were similar for the two groups, means of $13.25 .+-. 3.56 and and $13.21 .+-. 2.21 for clindamycin/gentamicin and clindamycin/aztreonam, respectively. Salaries for administering the antibiotics were not different between the two groups with a mean of $28.37 .+-. 7.63 for clindamycin/gentamicin and $28.29 .+-. SD $4.74 for clindamycin/aztreonam. Supplies for admixture and administration were significantly higher for clindamycin/gentamicin, mean $156.61 .+-. SD $42.12, than for clindamycin/aztreonam, $119.88 .+-. SD $20.09. The mean cost for gentamicin assay was $32.52 .+-. SD $9.00. The interpretation of the levels cost a mean of $50.18 .+-. $12.70. Thus the total costs for these activities that were unique to gentamicin were $82.70 .+-. $21.59. In summary, clindamycin/gentamin is a cheaper combination adjuvant the therapy for perforated/gangrenous appendicitis than clindamycin/aztreonam despite the costs associated with assay of gentamicin and salaries for monitoring.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 004568478

Download citation: RISBibTeXText

Related references

Surgically treated gangrenous or perforated appendicitis. A comparison of aztreonam and clindamycin versus gentamicin and clindamycin. Annals of Surgery 205(2): 133-137, 1987

Antibiotic management of surgically treated gangrenous or perforated appendicitis. Comparison of gentamicin and clindamycin versus cefamandole versus cefoperazone. American Journal of Surgery 144(1): 8-13, 1982

Antimicrobial management of surgically treated gangrenous or perforated appendicitis: comparison of cefoxitin and clindamycin-gentamicin. Clinical Therapeutics 9(4): 420-428, 1987

A Comparison of Aztreonam and Clindamycin versus Gentamicin and Clindamycin. Annals of Surgery 205(2): 133-137, 1987

Colorectal surgery: short-term prophylaxis with aztreonam plus clindamycin versus gentamicin plus clindamycin. Journal of ChemoTherapy 1(4 Suppl): 1008-1009, 1989

Pharmacoeconomics of aztreonam-clindamycin versus gentamicin-clindamycin in the treatment of penetrating abdominal injury. Pharmacotherapy. 16(5): 951-957, 1996

A randomized clinical trial of ampicillin, gentamicin and clindamycin versus cefotaxime and clindamycin in children with ruptured appendicitis. Surgery, Gynecology & Obstetrics 172(5): 351-356, 1991

Superiority of aztreonam/clindamycin compared with gentamicin/clindamycin in patients with penetrating abdominal trauma. American Journal of Surgery 167(3): 291-296, 1994

Clindamycin plus amikacin versus clindamycin plus aztreonam in established intraabdominal infections. Surgery 116(1): 28-35, 1994

Aztreonam plus clindamycin versus tobramycin plus clindamycin in the treatment of intraabdominal infections. Reviews of Infectious Diseases 13 Suppl 7: S629-S633, 1991

Aztreonam versus gentamicin, each with clindamycin, in the treatment of endometritis. Obstetrics and Gynecology 65(6): 825-829, 1985

Comparison of aztreonam plus clindamycin with tobramycin plus clindamycin in the treatment of intra-abdominal infections. ChemoTherapy 35 Suppl 1: 49-57, 1989

A Double-Blind, Randomized Comparison of Aztreonam Plus Clindamycin with Tobramycin Plus Clindamycin in Abdominal Infections. American Journal of Therapeutics 2(6): 373-377, 1995

Prospective randomized study of two different doses of clindamycin admixed with gentamicin in the management of perforated appendicitis. American Surgeon 59(4): 248-255, 1993

A clinical comparison of cefepime and metronidazole versus gentamicin and clindamycin in the antibiotic management of surgically treated advanced appendicitis. Surgery, Gynecology and Obstetrics 177 Suppl: 18-22; Discussion 35-40, 1993