A histopathological study on the cases following endoscopic injection sclerotherapy with intravariceal injection of aethoxysklerol for esophageal varices
Gastroenterological Endoscopy 30(1): 38-43
A histopathological study was made in ten autopsy cases after endoscopic injection sclerotherapy for esophageal varices (EIS) with intravariceal injection of 50% glucose, 1% Aethoxysklerol and human thrombin. Thrombi were observed in all ten cases. In two cases who died 12 and 24 hours after EIS, the thrombi revealed red thrombi. In three cases who died 1 and 2.5 months after EIS, organization of the thrombi was recognized. In three cases who survived 1 to 2 years after EIS, there was a increase in tissue fiber density in the thrombi. Microscopic recanalization developed 2.5 months after EIS. Cellular infiltration around the varices was present in the cases who died within 4 days after the last EIS. In the cases who survived more than 1 month, fibrosis was seen in the submucosal layer of the esophageal wall. These histopathological findings appear to support the effectiveness of EIS.