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A longitudinal study of offspring born to methadone maintained women 3. effects of multiple risk factors on development at 4 8 and 12 months



A longitudinal study of offspring born to methadone maintained women 3. effects of multiple risk factors on development at 4 8 and 12 months



American Journal of Drug and Alcohol Abuse 10(2): 195-208



Infants exposed to methadone in utero were compared to infants of drug-free women at 4, 8 and 12 mo. on 2 aspects of their behavior: motor coordination and attention. How differences between the methadone and comparison infants were affected by other family and medical risk factors were discussed. No matter what the level of other risk factors, methadone infants showed poorer motor coordination at 4 mo. and poorer attention at 12 mo. as a group than comparison infants. Family risk factors, however, did not modulate the strength and direction of differences between methadone and comparison infants. After 4 mo., methadone infants continued to show poorer motor coordination than comparison infants only in families with poorer resources (such as low SES [socioconomic status], maternal psychopathoogy and low intelligence, absence of father). Poorer early medical resources (pre- and perinatal complications) heightened the differences between methadone and comparison infants at early ages, but by the end of the 1st yr no longer played a role in modulating the drug effect. Methadone exposure in utero hs very limited teratological effects per se on the long-term development of infants, and that the pathology seen in some individual children is probably due to an interaction with other factors.

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Accession: 004581330

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