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A multi variate analysis of some operant variables used in behavioral pharmacology

A multi variate analysis of some operant variables used in behavioral pharmacology

Psychopharmacology 74(2): 182-186

The classificatory power afforded by the conjoint measurement of lever-pressing response rate and response duration was compared with a univariate analysis based exclusively on response rate. Operant behavior in rats was measured following chlorpromazine, haloperidol, chlordiazepoxide and pentobarbital, all of which produce similar dose-related decreases in rate of responding on simple fixed-ratio schedules of reinforcement. The multivariate technique of linear discriminant analysis indicates that both response rate and response duration provide useful and nonredundant information regarding the drug effect, separating the 4 drugs into 3 distinct classes: neuroleptic, chlordiazepoxide and pentobarbital.

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Accession: 004590331

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PMID: 6791224

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