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A randomized controlled trial of the effect on middle aged men of advice to stop smoking

A randomized controlled trial of the effect on middle aged men of advice to stop smoking

Journal of Epidemiology and Community Health 32(4): 275-281

A randomized controlled trial of smoking cessation is reported in 1445 male smokers aged 40-59 yr at high risk of cardiorespiratory disease. The 714 men in the intervention group were recalled for a series of personal interviews with a doctor. After 1 yr, 51% of the intervention group reported that they were not smoking any cigarettes; most of the others reported a reduction. Compared with the normal care group, the men in the intervention group showed a decline in the prevalence of sputum production and dyspnea; ventilatory function did not improve but its rate of decline was significantly slowed. There were no evident effects on blood pressure levels, nor on ECG findings over 3 yr, nor on sickness absence over 1 yr. Mortality follow-up continued for an average of 7.9 yr; 98 (13.7%) of the intervention group died, compared with 94 (12.9%) of the normal care group. The 95% confidence limits on mortality range from 2.63% in favor of intervention to 4.37% in favor of normal care. The power of the trial was reduced by smoking cessation in the normal care group. Smoking cessation in these middle-aged men improved the symptoms and progress of chronic bronchitis; but the reversibility of the risk of cigarettes to the smoker's life may be overestimated in observational studies.

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Accession: 004615433

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PMID: 370171

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