+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Aberration of b and t cell subsets in patients with immunoglobulin a nephropathy and membranous nephropathy



Aberration of b and t cell subsets in patients with immunoglobulin a nephropathy and membranous nephropathy



Tokai Journal of Experimental & Clinical Medicine 9(2): 95-102



Peripheral blood lymphocytes from 15 patients with IgA nephropathy (IgAN), 10 patients with membranous nephropathy (MN) and 15 healthy adults were examined to investigate whether there are any aberrations in B and T cell subsets in these dieases. F (ab')2 portions of heavy chain specific anti human IgG, IgA and IgM antibodies were used to determine isotypes of B lymphocytes and monoclonal antibodies directed at human T cells termed OKT3, OKT4 and OKT8 antibodies were used to assay subsets of T cells. Quantitation of B and T cell subsets was performed by flow cytometry. IgG, IgA and IgM bearing peripheral blood lymphocytes were significantly increased in patients with IgAN and MN, although the dominant class of immunoglobulin bearing cells in patients with IgAN was IgA bearing cells and that in patients with MN was IgM bearing cells. OKT4 positive (OKT4+) and OKT8 positive (OKT8+) cells were significantly decreased in both patient groups. The OKT4+/OKT8+ ratio increased only in MN patients without steroid therapy. Aberrations of B and T cell subsets are apparently common in both diseases.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 004644405

Download citation: RISBibTeXText


Related references

Aberration of B and T cell subsets in patients with IgA nephropathy and membranous nephropathy. Tokai Journal of Experimental and Clinical Medicine 9(2): 95, 1984

Evaluation of the staining findings of immunofluorescence in unfixed or fixed renal biopsy specimens from patients with immunoglobulin a nephropathy and membranous nephropathy. Acta Pathologica Japonica 35(2): 315-322, 1985

Complement c 5b 9 complex is found in subepithelial deposits of stage i idiopathic membranous nephropathy but not of stage i de novo membranous nephropathy and toxic induced membranous nephropathy. Kidney International 26(4): 633, 1984

Mononuclear cell subsets in patients with immunoglobulin a nephropathy. Laboratory Investigation 52(1): 65A, 1985

Correlation between histologic features and glomerular permeability in membranous nephropathy and immunoglobulin A nephropathy. Journal of Laboratory and Clinical Medicine 123(1): 94, 1994

Immunoglobulin (Gm) allotype frequencies in idiopathic membranous nephropathy and minimal change nephropathy. Transplantation 37(5): 507-508, 1984

Increased genetic risk of hypertension in immunoglobulin A nephropathy but not in membranous nephropathy. Journal of Hypertension. Supplement 9(6): S220-S221, 1991

IFI27 Is a Useful Genetic Marker for Diagnosis of Immunoglobulin A Nephropathy and Membranous Nephropathy Using Peripheral Blood. Plos one 11(4): E0153252, 2016

How many podocyte autophagosomes are there in immunoglobulin A nephropathy and idiopathic membranous nephropathy?. International Urology and Nephrology 48(12): 2109-2114, 2016

Immunoglobulin heavy chain switch region gene polymorphisms in idiopathic membranous nephropathy imn and iga nephropathy igan. Kidney International 35(1): 349, 1989

Long-term outcome of patients with lupus membranous nephropathy Comparison with idiopathic membranous nephropathy. Journal of the American Society of Nephrology 10(PROGRAM AND ABSTR ISSUE): 177A, 1999

Patients With Combined Membranous Nephropathy and Focal Segmental Glomerulosclerosis Have Comparable Clinical and Autoantibody Profiles With Primary Membranous Nephropathy: A Retrospective Observational Study. Medicine 95(21): E3786, 2016

Analysis of regulatory T cell subsets in the peripheral blood of immunoglobulin A nephropathy (IgAN) patients. Genetics and Molecular Research 14(4): 14088-14092, 2015

Correlation analysis of angiotensin-converting enzyme, angiotensinogen, and endothelial nitric oxide synthase gene polymorphisms and the progression of immunoglobulin A nephropathy/membranous nephropathy. Human Pathology 44(12): 2806-2813, 2013

AB0413Comparison of bucillamine-induced membranous nephropathy and non drug-induced membranous nephropathy in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases 71(Suppl 3): 661.4-661, 2013