Actinomycin D absorbed on polymethylcyanoacrylate nanoparticles: increased efficiency against an experimental tumor

Brasseur, F.; Couvreur, P.; Kante, B.; Deckers-Passau, L.; Roland, M.; Deckers, C.; Speiser, P.

European Journal of Cancer 16(11): 1441-1445


ISSN/ISBN: 0014-2964
PMID: 7227421
Accession: 004659536

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Preliminary results of experimental chemotherapy using actinomycin D loaded polymethylcyanoacrylate nanoparticles on the growth of transplantable rat soft tissue sarcoma [S 250] cells is described. The use of polymethylcyanoacrylate nanoparticles as a drug carrier apparently enhances the activity of the drug towards the subcutaneous sarcoma.