+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Activation of endogenous retroviral genomes in Mov strains of mice

Activation of endogenous retroviral genomes in Mov strains of mice

Journal of General Virology 68: 2919-2923

A collection of Mov mouse strains, each carrying in their germ line a Moloney murine leukaemia virus (M-MuLV) proviral genome at a different chromosomal location, was used to study expression of endogenous retroviruses. No M-MuLV-specific RNA was detected in the non-viraemic Mov strains studied, indicating that less than two copies of RNA are transcribed per cell. Virus expression was seen in three viraemic Mov strains. In Mov-3 mice the provirus was activated shortly after birth, whereas proviruses in Mov-9 and Mov-14 were activated at different stages of embryogenesis. The results suggest that the chromosomal position influences proviral expression during development. The first appearance of virus particles was not accompanied by detectable amounts of viral transcripts, suggesting that viraemia is a consequence of provirus activation in a small, as yet unidentified, population of cells, followed by virus spread and infection of susceptible cells.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 004663043

Download citation: RISBibTeXText

PMID: 3681267

DOI: 10.1099/0022-1317-68-11-2919

Related references

Activation of endogenous c type retroviral genomes by internal alpha irradiation of mice with radium 224. Radiation & Environmental Biophysics 24(1): 17-26, 1985

Activation of endogenous C-type retroviral genomes by internal alpha-irradiation of mice with 224Radium. Radiation and Environmental Biophysics 24(1): 17-25, 1985

The transmission and activation of endogenous mouse retroviral genomes. Trends in Genetics: 331-334, 1985

Chromosomal position and activation of retroviral genomes inserted into the germ line of mice. Journal of Cancer Research & Clinical Oncology 99(3): A84, 1981

Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice. Oncogene 27(3): 404-408, 2007

Methylation patterns of endogenous retroviral elements during activation of b lymphocyte populations in balb can mice. Journal of Cellular Biochemistry Supplement (14 PART D): 226, 1990

A new class of endogenous human retroviral genomes. Science 228(4704): 1208-1211, 1985

Two families of human endogenous retroviral genomes. Lambert, M E , J F Mcdonald And I B Weinstein (Ed ) Banbury Report, Vol 30 Eukaryotic Transposable Elements As Mutagenic Agents; Conference, Cold Spring Harbor, New York, Usa, April 21, 1987 Xvi+345p Cold Spring Harbor Laboratory: Cold Spring Harbor, New York, Usa Illus 91-100, 1988

Chromosomal locations of members of a family of novel endogenous human retroviral genomes. Journal of Virology 58(3): 955-959, 1986

Molecular screening of xenodonor genomes for species-specific endogenous retroviral DNA sequences. Transplantation Proceedings 29(1-2): 897-898, 1997

Cloning and characterization of the endogenous retroviral-tRNA-Glu multigene family from human genomes of different racial backgrounds. Gene (amsterdam). 155(2): 247-252, 1995

Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues. Proceedings of the National Academy of Sciences of the United States of America 82(5): 1451-1455, 1985

Simulation of the distribution of parental strains' genomes in RC strains of mice. Mammalian Genome 8(12): 884-889, 1997