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Activity of deoxy inosine activated nucleotidase in lymphoid tissues and circulating cells

Activity of deoxy inosine activated nucleotidase in lymphoid tissues and circulating cells

International Journal of Biochemistry 13(4): 417-422

Deoxyinosine-activated 5'(3)-nucleotidase (DIAN) was present in high amounts in lymphoid tissues of the rat (lymph nodes > spleen > thymus > bone marrow). The activity of rat spleen increased with the age of the animal. DIAN activity of circulating blood cells and peritoneal macrophages was low. A deoxyinosine-activated nucleotidase with very similar properties was found in rabbit liver and spleen and in human blood cells. A close similarity in tissue distribution existed between the DIAN and adenosine deaminase.

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Accession: 004666738

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PMID: 6263729

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