EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Acute effects of smoking marihuana on hormones subjective effects and performance in male human subjects



Acute effects of smoking marihuana on hormones subjective effects and performance in male human subjects



Pharmacology Biochemistry & Behavior 24(6): 1749-1754



Four healthy male subjects smoked two marijuana cigarettes or one marijuana cigarette and one placebo cigarette, or two placebo cigarettes on separate days in a random order crossover design. Each marijuana cigarette contained 2.8% delta-9-tetrahydrocannabinol (THC). Plasma hormones and THC were measured before and after each smoking session. Plasma LH was significantly depressed and cortisol was significantly elevated after smoking marijuana. Nonsignificant depressions of prolactin, FSH, testosterone and free testosterone and elevation of GH also occurred. Concurrent measures of subjective effects via subscales of the Addiction Research Center Inventory, Single Dose Questionnaire and a Visual Analog Scale were generally elevated. Significant impairment on a psychomotor performance task paralleled elevations in subjective effects, hormone effects and peak THC determinations. Although all the hormone effects were within normal basal ranges, interactions between these systems, and their effects on behaviour cannot be discounted.

(PDF 0-2 workdays service: $29.90)

Accession: 004669801

Download citation: RISBibTeXText

PMID: 3016764



Related references

Clonidine partially blocks the physiologic effects but not the subjective effects produced by smoking marihuana in male human subjects. Pharmacology Biochemistry & Behavior 29(3): 649-652, 1988

Effects of marihuana on human cigarette smoking and subjective ratings. Pharmacology Biochemistry & Behavior 22(6): 1080, 1985

Ethanol increases plasma Delta(9)-tetrahydrocannabinol (THC) levels and subjective effects after marihuana smoking in human volunteers. Drug and Alcohol Dependence 64(2): 143-149, 2001

Acute effects of marihuana smoking on maximal exercise performance. Medicine and Science in Sports and Exercise 18(6): 685-689, 1986

Effects of marihuana smoking on subjective ratings and tobacco smoking. Pharmacology Biochemistry & Behavior 25(3): 659-666, 1986

Comparative effects of smoking marihuana or placebo on human motor and mental performance. Clinical Pharmacology and Therapeutics 11(6): 808-815, 1970

Acute effects of marihuana smoking on prolactin levels in human females. Journal of Pharmacology and Experimental Therapeutics 232(1): 220-222, 1985

Effects of marihuana on testosterone in male subjects. Journal of Theoretical Biology 104(4): 685-692, 1983

The effects of smoking marihuana on physical performance. Medicine and Science in Sports 7(4): 309-311, 1975

Marihuana smoking increases plasma cocaine levels and subjective reports of euphoria in male volunteers. Pharmacology Biochemistry & Behavior. 48(3): 715-721, 1994

Effects of acute marihuana smoking in postmenopausal women. Psychopharmacology 90(1): 14-17, 1986