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Additive inhibitory effects of combinations of fluoride and chlorhexidine on acid production by Streptococcus mutans and Streptococcus sanguis



Additive inhibitory effects of combinations of fluoride and chlorhexidine on acid production by Streptococcus mutans and Streptococcus sanguis



Caries Research 19(1): 64-71



The effect of 0.07 or 0.15 mM chlorhexidine (CHX) and 4.0 or 8.0 mM potassium fluoride (F-), added singly and in combinations, on acid production by S. mutans and S. sanguis was studied. Cells were grown in a chemostat under different environmental conditions and acid production from glucose or sucrose was measured as a rate at pH 7.0 and by pH-fall experiments. CHX had a greater inhibitory action on S. mutans while S. sanguis was more sensitive to F-. Growth conditions affected the sensitivity of both strains to the 2 inhibitors and, in general, cells grown glucose-limited were the most sensitive. Combinations of F- and CHX showed additive inhibitory effects on acid production, irrespective of the method of measurement.

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Accession: 004676110

Download citation: RISBibTeXText

PMID: 3856486

DOI: 10.1159/000260830


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