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Adeno squamous carcinoma of skin appendages adenoid squamous cell carcinoma pseudoglandular squamous cell carcinoma adeno acanthoma of sweat gland of lever of the vulva a clinical and ultrastructural study



Adeno squamous carcinoma of skin appendages adenoid squamous cell carcinoma pseudoglandular squamous cell carcinoma adeno acanthoma of sweat gland of lever of the vulva a clinical and ultrastructural study



Cancer 42(4): 1851-1858



History and clinical findings of 18 cases of adenosquamous carcinoma of the skin appendages found among 135 cases of primary carcinoma of the vulva were analyzed. In addition, 2 recent cases of this tumor were studied with conventional transmission electron microscopy. Adenosquamous carcinoma of the vulva showed poorer survival and a higher rate of lymph node metastases than squamous cell carcinoma of the corresponding stages (carcinoma in situ excluded). In 4 out of 13 cases, the metastatic lesions in the lymph nodes retained glandular pattern. The ultrastructure showed mucin-producing columnar cells lining glandular lumina, and poorly differentiated squamous cells elsewhere; further, cells of the intermediate type between the 2 were present. This study indicates that adenosquamous carcinoma of the vulva is a distinctively separate entity from squamous cell carcinoma of the vulva, and possibly arises from mucin-producing cells of the skin appendages as suggested by Johnson and Helwig.

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Accession: 004676619

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PMID: 709534



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