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Adeno squamous carcinoma of the gall bladder accompanied by synchronous gastric cancer

Adeno squamous carcinoma of the gall bladder accompanied by synchronous gastric cancer

Gastroenterological Endoscopy 29(12): 3109-3114

A 75-year-old female admitted to our hospital because of right hypochondralgia and back pain. Ultrasonography, computed tomography, ERCP and angiography showed the findings of the gall bladder cancer invaded into the liver. According to the encasement of the portal vein and gastroduodenal artery, the operative treatment was thought to be impossible, so one shot therapy of Mitomycin C (MMC) into the gastroduodenal artery was done. After the therapy, she had melena. Endoscopic findings revealed the bleeding from gastric cancer, Borrmann III type on the posterior wall of the upper body. Bleeding was stopped conservatively. One shot therapy of MMC and Adriamycin into the feeding artery of the gall bladder cancer and gastric cancer was done twice, and two weeks after the last therapy she had died of blood loss from gastric cancer. Autopsy revealed the adeno-squamous carcinoma of the gall bladder and adenocarcinoma of the stomach, namely synchronous double cancers. Acccording to literature, there were 9 cases of the double cancers of the gall bladder and stomach in Japan. Clinical diagnosis of such cases may increase owing to the development of ultrasonography and endoscopy. Only one case of the same histological combination of this type of double cancers was reported in Japan previously. The origin and cause of adeno-squamous carcinoma of the gall bladder is also discussed.

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