Adenylate cyclase of human gastric mucosa. Stimulation of enzyme activity by histamine and catecholamines

Simon, B.; Kather, H.

Digestion 16(1-2): 175-179

1977


ISSN/ISBN: 0012-2823
PMID: 28260
DOI: 10.1159/000198069
Accession: 004677875

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Abstract
Human gastric mucosal adenylate cyclase has been shown to be sensitive to histamine and catecholamines. Stimulation of enzyme activity by histamine and catecholamines were selectively blocked by cimetidine and propranolol, respectively. Combination of both hormones at maximally effective concentrations were additive, indicating that human gastric mucosa contains at least two separate hormone-sensitive adenylate cyclases.