Adjuvant polyarthritis. VI. Effect of oxonate-induced hyperuricemia on the development of acute inflammation, immune response and adjuvant arthritis

Chang, Y.H.; Bluestone, R.

Journal of Pharmacology and Experimental Therapeutics 219(3): 731-734


ISSN/ISBN: 0022-3565
PMID: 6975369
Accession: 004679156

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In humans, there is a negative correlation between gout and rheumatoid arthritis. Similarly, rats rendered hyperuricemic by an oxonate diet appeared resistant to develop adjuvant arthritis. These animals exhibited a normal inflammatory response to a subplantar injection of carrageen and normal humoral and cell-mediated immune responses to a sensitizing dose of EL4 cells. Unlike that of normal animals, the cell-mediated immune system of the oxonate-treated rats was unable to respond to adjuvant stimulation, which may be the basis for their resistance to develop adjuvant disease.