+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Adrenocortical responsiveness in neonates weaned from the ventilator with dexamethasone



Adrenocortical responsiveness in neonates weaned from the ventilator with dexamethasone



Australian Paediatric Journal 23(4): 227-230



Adrencortical responsiveness was assessed in eight very low birthweight neonates who had bronchopulmonary dysplasia and had been weaned from mechanical ventilation using dexamethasone. Three of the eight infants did not respond to ACTH stimulation during the first week after cessation of dexamethasone, but all three responded normally when retested at least 1 month later. The present authors have thus demonstrated that some infants have at least temporary adrenocortical unresponsiveness after prolonged courses of glucocorticoid therapy, and suggest that adrenocortical function should be assessed in all infants who are weaned from mechanical ventilation using dexamethasone.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 004681266

Download citation: RISBibTeXText

PMID: 2827616

DOI: 10.1111/j.1440-1754.1987.tb00255.x


Related references

Effect of vitamin E on the adrenocortical responsiveness of weaned piglets. Acta Veterinaria Brno 44(3): 155-162, 1975

The effect of dexamethasone on adrenal responsiveness in ventilator dependent preterm infants with bronchopulmonary dysplasia bpd. American Review of Respiratory Disease 135(4 Part 2): A125, 1987

One-week versus 2-day ventilator circuit change in neonates with prolonged ventilation: cost-effectiveness and impact on ventilator-associated pneumonia. Infection Control and Hospital Epidemiology 36(3): 287-293, 2015

ACTH secretion and adrenocortical responsiveness in Cushing's syndrome due to adrenocortical hyperplasia. Nihon Naibunpi Gakkai Zasshi 52(8): 828-844, 1976

Clinical usefulness of the monitoring of the thorax movement for the postoperative neonates with congenital heart disease a preliminary study for developing a new volume limited ventilator for neonates. Respiration & Circulation 36(7): 767-771, 1988

Clinical usefulness of the monitoring of thorax movement for postoperative neonates with congenital heart disease--a preliminary study for developing a new volume-limited ventilator for neonates. Kokyu to Junkan. Respiration and Circulation 36(7): 767-771, 1988

An asthmatic weaned from a ventilator using a laryngeal mask. Anaesthesia 50(5): 454-455, 1995

The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits. Journal of Clinical Endocrinology and Metabolism 94(7): 2406-2413, 2009

The combined dexamethasone/corticotropin-releasing hormone stimulation test is more closely associated with features of diurnal activity of the hypothalamo-pituitary-adrenocortical system than the dexamethasone suppression test. Biological Psychiatry 43(10): 762-766, 1998

Effects of long chain saturated fatty acids on membrane microviscosity and acth responsiveness of human adrenocortical cells and hlh binding and responsiveness of leydig tumor cells ma 10 in vitro. Uziel, G , R J A Wanders And M Cappa (Ed ) International Congress Series, 898 Adrenoleukodystrophy And Other Peroxisomal Disorders: Clinical, Biochemical, Genetic And Therapeutic Aspects; International Workshop, Rome, Italy, November 10-11, 1989 Viii+207p Elsevier Science Publishers B V (Biomedical Division): Amsterdam, Netherlands; (Dist in The Usa And Canada By Elsevier Science Publishing Co , Inc : New York, New York) Illus 67-80, 1990

Use of theophylline in neonates as an aid to ventilator weaning. Therapeutic Drug Monitoring 14(6): 471-474, 1992

Cutaneous monitoring of systemic PCO2 on patients in the respiratory intensive care unit being weaned from the ventilator. Acta Anaesthesiologica Scandinavica. Supplementum 68: 123-127, 1978

Mortality and readmission among ventilator-dependent patients after successful weaned discharge from a respiratory care ward. Journal of the Formosan Medical Association 109(6): 446-455, 2010

Efficacy of synchronized IMV on weaning neonates from the ventilator. Acta Paediatrica Japonica 36(2): 162-166, 1994

Strategies to prevent ventilator-associated pneumonia in neonates. Clinics in Perinatology 37(3): 629-643, 2010