Adult t cell leukemia lymphoma associated with human t cell leukemia lymphoma virus type i in martinique i french west indies a report of two cases

De The G.

Nouvelle Revue Francaise d'Hematologie 28(2): 107-114


ISSN/ISBN: 0029-4810
Accession: 004682768

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Two HTLV-I associated adult T cell leukemia cases were observed in patients from Martinique (French West Indies). These cases are similar to the clinical entity, described by Takatsuki in 1977 in Japan and by Catovsky in Caribbean patients, characterized by a lymphadenopathy, skin lesions and visceral involvement, hypercalcemia, an aggressive course, and poor prognosis. The malignant cells with T4 phenotype and often suppressive function, were pleomorphic, mature, with prominent nuclear irregularities. Systematic research of HTLV-I virus or antibodies in patients with this clinical picture, to measure the influence of this virus in T cell lymphoproliferative diseases in France and in French West Indies is required.