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Albumin and immuno globulin in plasma and cerebro spinal fluid and blood cerebro spinal fluid barrier function in patients with dementia of the alzheimer type and multi infarct dementia



Albumin and immuno globulin in plasma and cerebro spinal fluid and blood cerebro spinal fluid barrier function in patients with dementia of the alzheimer type and multi infarct dementia



Journal of the Neurological Sciences 60(3): 465-472



Plasma and CSF from 20 patients with Alzheimer's dementia or senile dementia of Alzheimer type (AD/SDAT), 23 with multi-infarct dementia (MID) and 16 controls were assayed for their content of Ig and albumin (Alb). The concentrations of IgG and Alb were used to analyze the blood-CSF barrier function in the respective group. MID patients had significantly (P < 0.001) elevated plasma IgG levels compared to controls and AD/SDAT patients. CSF concentration of Alb was significantly higher in MID (P < 0.01) and AD/SDAT (P < 0.05) patients compared to the controls. Concentration of CSF IgG was significantly (P < 0.05) lower in AD/SDAT patients compared to the MID patients; no significant differences were found when CSF concentrations of IgG of demented patients were compared to controls. A blood-CSF barrier dysfunction may be indicated, especially in cases with MID with significantly (P < 0.001) elevated values of transudation. These findings indicate a non-specific and/or specific binding of IgG in CNS tissue and/or vessel walls in both forms of dementia on the basis of low IgG ratios compared to proportionally higher Alb ratios. There were no signs of local synthesis of IgG in CNS in either group of demented patients.

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