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Alkaline shift in lumbar and intra cranial cerebro spinal fluid in man after 5 days at high altitude



Alkaline shift in lumbar and intra cranial cerebro spinal fluid in man after 5 days at high altitude



Journal of Applied Physiology 41(1): 93-97



In 6 healthy male volunteers at sea level (PB [barometric pressure] 747-759 Torr), pH and PCO2 [partial CO2 pressure] in CSF and in arterial and jugular bulb blood were measured from these data. PCO2 and pH for the intracranial portion of CSF were estimated. The measurements were repeated after 5 days in a hypobaric chamber (PB 447 Torr). Both lumbar and intracranial CSF were significantly more alkaline at simulated altitude than at sea level. Decrease in [HCO3-] in lumbar CSF at altitude was similar to that in blood plasma. Both at sea level and at high altitude, PCO2 measured in the lumbar CSF was higher than that estimated for the intracranial CSF. At altitude, hyperoxia, in comparison with breathing room air, resulted in an increase in intracranial PCO2, and a decrease in the estimated pH in intracranial CSF. With hyperoxia at altitude, alveolar ventilation was significantly higher than during sea-level hyperoxia or normoxia, confirming that a degree of acclimatization had occurred. Changes in cerebral arteriovenous differences in CO2, measured in 3 subjects, suggest that cerebral blood flow was elevated after 5 days at altitude.

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Accession: 004696800

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